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PGT-A
Preimplantation Genetic Testing for Aneuploidy
Preimplantation Genetic Testing for Aneuploidy (PGT-A) is an advanced reproductive technology used during in vitro fertilization (IVF) to screen embryos for chromosomal abnormalities. Aneuploidy refers to an abnormal number of chromosomes, which can lead to implantation failure, miscarriage, or genetic disorders such as Down syndrome. By identifying chromosomally normal embryos, PGT-A aims to improve the chances of a successful pregnancy and healthy live birth.
Indications for PGT-A
PGT-A is recommended for individuals or couples in the following situations:
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Advanced Maternal Age (≥35 years)
Risk of embryonic aneuploidy increases with age.
Recurrent Pregnancy Loss
Multiple miscarriages may indicate chromosomal abnormalities in embryos.
Repeated IVF Failure
Unexplained failed implantation cycles.
Balanced Chromosomal Rearrangements
Carriers of translocations or inversions (though PGT for structural rearrangements is technically PGT-SR).
Family Planning
To reduce the risk of transferring embryos with severe chromosomal disorders.
Benefits of PGT-A
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Higher Pregnancy Rates
Reduces the likelihood of transferring embryos with lethal abnormalities.
Lower Miscarriage Risk
Aneuploidy accounts for ~50% of early miscarriages; PGT-A minimizes this risk.
Reduced Time to Pregnancy
Avoids multiple unsuccessful transfers.
Single Embryo Transfer (SET)
Lowers the risk of multiples (twins/triplets) while maintaining success rates.
Informed Decision-Making
Provides clarity for patients with recurrent IVF failures or genetic concerns.
How It Works:PGT-A
Discover the sequential process of PGT - A, from the initial IVF cycle to the final selection of chromosomally normal embryos for a higher chance of successful implantation.
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Eggs are retrieved, fertilized with sperm, and cultured to the blastocyst stage (Day 5–6).
A few cells from the trophectoderm (future placenta) are gently removed for genetic analysis.
Using next-generation sequencing (NGS) or microarray technology, the cells are screened for chromosomal abnormalities (e.g., missing or extra chromosomes).
Only euploid (chromosomally normal) embryos are selected for transfer, optimizing implantation success.
FAQ
Yes, they can be transferred without PGT. While it may appear that third-generation IVF (with PGT screening) results in fewer transferable embryos, in reality, the screening filters out embryos with significant chromosomal abnormalities in advance. This means PGT actually improves the success rate per transfer and reduces the time and financial costs associated with trial-and-error transfers.
The definition of success should not be limited to the number of embryos obtained, but should focus more on the success rate per transfer and the live birth rate. Therefore, we generally recommend undergoing PGT.